--- title: New Study Co-Authored By InsightRX Shows Model-Informed Precision Dosing Could Improve Efficacy Of Hematopoietic Cell Transplants While Reducing Toxicity description: Study shows TDM and Bayesian dosing model co-developed by InsightRX achieves busulfan exposure with substantially more precision than conventional dosing. image: https://blog.insight-rx.com/hubfs/New-Study-Co-Authored-By-InsightRX-Shows-Model-Informed-Precision-Dosing-Could-Improve-Efficacy-Of-Hematopoietic-Cell-Transplants-While-Reducing-Toxicity.png --- [![InsightRX](https://blog.insight-rx.com/hubfs/insightrx_logo_white-teal.svg)](https://blog.insight-rx.com/) - For Providers - Solutions - [MIPD for Providers Explore our full solution for Bayesian model-informed dosing](https://www.insight-rx.com/mipd) - [Future of Pharmacy Learn what's next for AI in health tech, and why architecture matters](https://www.insight-rx.com/future) - Products - [InsightRX Nova Bayesian dosing (MIPD) app for bedside clinical decision support](https://www.insight-rx.com/provider/nova) - [InsightRX Apollo Real-time clinical analytics to measure outcomes](https://www.insight-rx.com/provider/apollo) - [Drug Modules Available medications for precision dosing apps](https://www.insight-rx.com/provider/drug-modules) - [For Life Sciences](https://www.insight-rx.com/life-sciences) - Overview - [InsightRX for Life Sciences Explore our solution for biopharma and clinical trial use](https://www.insight-rx.com/life-sciences) - Products - [Nova for Life Sciences Precision dosing app for clinical trial use](https://www.insight-rx.com/life-sciences/nova) - [Astra for Life Sciences AI-native environment for PK/PD modeling and simulation](https://www.insight-rx.com/life-sciences/astra) - Platform - [Continuous Learning Patented process for model retraining and improvement](https://www.insight-rx.com/platform/continuous-learning) - [Integrations Platform interoperability setup with EHRs, EDCs, and more](https://www.insight-rx.com/platform/integrations) - [Security & Regulatory Standards for product development and release](https://www.insight-rx.com/platform/security-regulatory) - [Success & Support Pharmacist-led training, onboarding, and education](https://www.insight-rx.com/platform/support) - Resources - Science - [Data Science Explore the science and learn more about our R&D](https://www.insight-rx.com/data-science) - [Scientific Publications Impactful research manuscripts with at least one InsightRX author](https://www.insight-rx.com/data-science/scientific-publications) - [How to Cite Using one of our apps? Follow this easy guide for citation in research](https://www.insight-rx.com/how-to-cite-insightrx-nova) - Explore - [Success Stories Case studies from real InsightRX customers about their journey](https://www.insight-rx.com/success-stories) - [White Papers In-depth analysis and best practices for review and download](https://blog.insight-rx.com/resources/tag/white-papers) - [Pubs. Using InsightRX Review research that has used InsightRX applications](https://www.insight-rx.com/publications-using-insightrx-software) - [Blog](https://blog.insight-rx.com/resources) - [All Blog Posts Read the latest posts by our team of experts](https://blog.insight-rx.com/resources) - [Product Innovation The latest updates on our products, services, and science](https://blog.insight-rx.com/resources?section=product_innovation) - [Thought Leadership Posts from our team of experts on PK, MIPD, science, and more](https://blog.insight-rx.com/resources?section=thought_leadership) - Company - About - [About Us Our story, what drives us and why we're passionate about our work](https://www.insight-rx.com/about) - [Leadership Founders and team leaders who strive toward excellence in MIPD](https://www.insight-rx.com/leadership) - [Advisory Board Scientists and experts to ensure our collective success](https://www.insight-rx.com/advisory-board) - [Careers Interested in joining? View available openings here](https://www.insight-rx.com/careers) - [Customers Hear what others have to say about their experience](https://www.insight-rx.com/customers) - Press - [All Stories InsightRX news, company updates, and more](https://blog.insight-rx.com/press-releases) - [Press Releases Announcements for events, partnerships, and company updates](https://blog.insight-rx.com/press-releases?section=press_releases) - [Media InsightRX in the news — digital, print, podcasts, and other outlets](https://blog.insight-rx.com/press-releases?section=media) [![Contact Us](https://no-cache.hubspot.com/cta/default/40041574/interactive-193831493462.png)](https://cta-service-cms2.hubspot.com/web-interactives/public/v1/track/redirect?encryptedPayload=AVxigLIVhNAV4frdGw7WK4%2FsUL9BSW7sTFfaUWeB6c0miW6Ak22RBUNE5R8BeaQrWqzDSork53FkrNEqiSn%2FTM4f%2BVzPNcA0Ikxp7y6GqZRUQJ2HulFNF849cXXSebQBDVQXFR3hVvn8tZ3jkxYoygqRgjFUwIOapgI0FM8UFCm2xhxz2SgLhEGqk1U%3D&webInteractiveContentId=193831493462&portalId=40041574) [![Contact Us](https://no-cache.hubspot.com/cta/default/40041574/interactive-193831493462.png)](https://cta-service-cms2.hubspot.com/web-interactives/public/v1/track/redirect?encryptedPayload=AVxigLIVhNAV4frdGw7WK4%2FsUL9BSW7sTFfaUWeB6c0miW6Ak22RBUNE5R8BeaQrWqzDSork53FkrNEqiSn%2FTM4f%2BVzPNcA0Ikxp7y6GqZRUQJ2HulFNF849cXXSebQBDVQXFR3hVvn8tZ3jkxYoygqRgjFUwIOapgI0FM8UFCm2xhxz2SgLhEGqk1U%3D&webInteractiveContentId=193831493462&portalId=40041574) Press Releases # New Study Co-Authored By InsightRX Shows Model-Informed Precision Dosing Could Improve Efficacy Of Hematopoietic Cell Transplants While Reducing Toxicity - Published July 30, 2020 By [InsightRX Communications](https://blog.insight-rx.com/press-releases/author/insightrx) ![](https://blog.insight-rx.com/hubfs/New-Study-Co-Authored-By-InsightRX-Shows-Model-Informed-Precision-Dosing-Could-Improve-Efficacy-Of-Hematopoietic-Cell-Transplants-While-Reducing-Toxicity.png) SAN FRANCISCO, July 30, 2020 /PRNewswire/ — Researchers at the University of California, San Francisco (UCSF) and healthcare technology company InsightRX demonstrated that a second-generation Bayesian pharmacokinetic (PK) model enabled highly accurate and repeatable target attainment for busulfan, a conditioning agent typically used in hematopoietic cell transplants (HCTs). Busulfan is used in conditioning regimens before HCT for a variety of diseases including hematological malignancies, and increasingly in gene therapy. The drug has a narrow therapeutic index, meaning that dosing must be continually monitored and adjusted in order to maximize efficacy while reducing the likelihood of adverse drug events. 100% of patients dosed using the second-generation PK model with Bayesian forecasting achieved the target range of cumulative busulfan exposure (cAUC), as compared to 66% using the manufacturer’s package insert and 88% using a first-generation PK model and non-compartmental analysis. The coefficient of variation, a measure of spread in target attainment, was 4.1% for patients dosed with the second-generation PK model, as compared to 14.8% and 17.1% for patients dosed using the package insert and first-generation model, respectively. This shows that the second-generation model provided a significant advantage over conventional dosing approaches to achieve target drug exposure. > “Accurately and precisely hitting busulfan dosing targets will reduce drug-related toxicity as well as increase the chance that HCT is successful in controlling a patient’s disease,” said Janel Long-Boyle, Associate Professor of Clinical Pharmacy at UCSF and principal investigator of the study. “InsightRX has been a great partner in developing these innovative methods that can ultimately save lives.” Clinicians and researchers at UCSF worked with InsightRX to develop the second-generation Bayesian PK model and implement it using InsightRX’s cloud-based clinical decision support platform. The second-generation model takes into account individual patients’ factors including age, body size and composition, and co-administration of other conditioning drugs, to provide individualized busulfan dosing regimens that improve clinical target attainment. The study, [published this month in Frontiers in Pharmacology](https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2020.00888/full), a leading peer-reviewed pharmacology journal, details the development of the second-generation model and assessment of its accuracy and precision at achieving target busulfan exposure in children undergoing HCT, compared to conventional dosing methods. InsightRX co-founders Sirj Goswami and Ron Keizer co-authored the study. > “This milestone shows InsightRX’s commitment to making meaningful scientific contributions that improve patient outcomes, as well as deploying these solutions to the point of care,” said Sirj Goswami, InsightRX CEO and co-founder. “We look forward to helping InsightRX customers deliver superior patient care that can both save lives and cut costs.” InsightRX helps hospitals and health systems transition from one-size-fits-all drug dosing to individualized dosing at the point of care. With a cloud-based precision dosing platform, InsightRX leverages patient-specific data, quantitative pharmacology models, and machine learning to understand each patient’s pharmacological profile to guide treatment decisions. InsightRX’s end-to-end precision dosing solution enables health systems to predict and optimize dosing regimens, reach and maintain clinical targets, measure performance, and monitor clinical outcomes. InsightRX recently [announced a $10 million Series A funding](https://blog.insight-rx.com/press-releases/healthcare-technology-startup-raises-10-million-precision-dosing-point-of-care). [busulfan](https://blog.insight-rx.com/press-releases/tag/busulfan) [transplant](https://blog.insight-rx.com/press-releases/tag/transplant) [BMT](https://blog.insight-rx.com/press-releases/tag/bmt) [MIPD](https://blog.insight-rx.com/press-releases/tag/mipd) [clinical evidence](https://blog.insight-rx.com/press-releases/tag/clinical-evidence) #### On this page… **Connect with us to get the latest blog updates, instantly sent to your inbox** ## Dig deeper. Explore related articles and additional posts on the InsightRX blog. [Press Releases Mar 29, 2022 InsightRX Reports Record Growth In Platform Adoption By Health Systems And Biopharma Companies](https://blog.insight-rx.com/press-releases/record-growth-platform-adoption-health-systems-biopharma-companies) [Press Releases Dec 4, 2025 InsightRX Surpasses 1,000 Hospital Deployments as the Most Widely Used AI Precision Dosing Software](https://blog.insight-rx.com/press-releases/insightrx-surpasses-1000-customer-sites) [Press Releases Aug 27, 2024 InsightRX Announces the Release of InsightRX GEMINI Model-selection Algorithm](https://blog.insight-rx.com/press-releases/insightrx-gemini-model-selection-algorithm-release) #### What We Do ##### For Providers - [Nova (Bayesian Dosing)](https://www.insight-rx.com/provider/nova) - [Apollo (Clinical Analytics)](https://www.insight-rx.com/provider/apollo) - [Drug Modules](https://www.insight-rx.com/provider/drug-modules) ##### For Life Sciences - [Nova (MIPD for Clinical Trials)](https://www.insight-rx.com/life-sciences/nova) - [Astra (AI-Powered Clin Pharm)](https://www.insight-rx.com/life-sciences/astra) - [Companion Applications](https://www.insight-rx.com/life-sciences/nova#companion-applications) #### How We Do It ##### Platform - [Continuous Learning](https://www.insight-rx.com/platform/continuous-learning) - [Integrations](https://www.insight-rx.com/platform/integrations) - [Security & Regulatory](https://www.insight-rx.com/platform/security-regulatory) - [Success & Support](https://www.insight-rx.com/platform/success-support) ##### Science - [Data Science](https://www.insight-rx.com/data-science) - [Scientific Publications](https://www.insight-rx.com/data-science/scientific-publications) #### Information ##### Resources - [Success Stories](https://www.insight-rx.com/success-stories) - [White Papers](https://www.insight-rx.com/white-papers) - [Publications Using InsightRX](https://www.insight-rx.com/publications-using-insightrx-software) - [How to Cite InsightRX](https://www.insight-rx.com/how-to-cite-insightrx-nova) ##### Blog - [All Posts](https://blog.insight-rx.com/resources) - [Product Innovation](https://blog.insight-rx.com/resources?section=product_innovation) - [Thought Leadership](https://blog.insight-rx.com/resources?section=thought_leadership) #### About - [Our Story](https://www.insight-rx.com/about) - [Leadership](https://www.insight-rx.com/leadership) - [Advisory Board](https://www.insight-rx.com/advisory-board) - [Our Customers](https://www.insight-rx.com/customers) - [Press Releases](https://blog.insight-rx.com/press-releases?section=press_releases) - [Media](https://blog.insight-rx.com/press-releases?section=media) - [Careers](https://www.insight-rx.com/careers) - [Contact](https://www.insight-rx.com/contact-us) --- ![CE marking](https://blog.insight-rx.com/hubfs/ce-mark-white.svg) InsightRX Nova is HITRUST CSF r2 certified, CE marked, and 21 CFR Part 11 compliant. Our quality management, risk management, software lifecycle, and usability engineering processes conform to ISO 13485, IEC 62304, ISO 14971, IEC 62366-1, and IEC 82304-1. InsightRX Nova is not considered to be a medical device in the U.S. and has not been submitted to the U.S. Food and Drug Administration for review or clearance. 740-05000-REC-01 · 08/2025 --- [![InsightRX](https://blog.insight-rx.com/hubfs/insightrx_logo_white-teal.svg)](https://www.insight-rx.com/) 548 Market Street #88083 San Francisco, CA 94104 --- © 2026 InsightRX, Inc. All rights reserved. [Privacy Policy](https://www.insight-rx.com/privacy-policy) Cookie Preferences ```json { "@context" : "https://schema.org", "@type" : "BlogPosting", "author" : { "@type" : "Person", "name" : "InsightRX Communications", "url" : "https://blog.insight-rx.com/press-releases/author/insightrx" }, "dateModified" : "2025-12-15T00:12:02.060Z", "datePublished" : "2020-07-30T22:12:00.000Z", "headline" : "New Study Co-Authored By InsightRX Shows Model-Informed Precision Dosing Could Improve Efficacy Of Hematopoietic Cell Transplants While Reducing Toxicity", "image" : [ "https://blog.insight-rx.com/hubfs/New-Study-Co-Authored-By-InsightRX-Shows-Model-Informed-Precision-Dosing-Could-Improve-Efficacy-Of-Hematopoietic-Cell-Transplants-While-Reducing-Toxicity.png" ], "mainEntityOfPage" : { "@id" : "https://blog.insight-rx.com/press-releases/model-informed-precision-dosing-hematopoietic-cell-transplants-reducing-toxicity", "@type" : "WebPage" }, "publisher" : { "@type" : "Organization", "logo" : { "@type" : "ImageObject", "url" : "https://blog.insight-rx.com/hubfs/insightrx_logo_color%20500%20x%20250-1.png" }, "name" : "InsightRX" } } ```